Albert Zlotnik,Jose L. Maravillasmontero,Amanda M. Burkhardt
申请号：
US15023493
公开号：
US20160368995A1
申请日:
2014.09.30
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Method of treating a subject for a disorder that correlates to increased CXCR8 signaling. The method includes disrupting the activation of receptor CXCR8 by ligand CXCL17 in the subject. In the method, the disrupting can include administering to the subject a substance that interferes with CXCL17 binding to CXCR8. Methods of screening, ligands, agonists, antagonists and vaccines involving the CXCR8/CXCL17 axis are also provided.
