1. The compound of formula I: Formula I or a pharmaceutically acceptable salt, hydrate, solvate, enantiomer, stereoisomer or tautomer thereof, wherein: X1 is halogen； X2 is halogen； Y is O, -NH； each R1 is individually and independently halogen, H, CC-alkyl, branched CC-alkyl, CC-cycloalkyl, CC-alkoxy, branched CC-alkoxy or cyano； each R2 individually and independently represents CC-alkyl, deutero-CC-alkyl, where the alkyl radical may be partially or fully deuterated, branched C -C-alkyl, branched deutero-CC-alkyl, where the alkyl residue may be partially or fully deuterated, CC-cycloalkyl, CC-alkoxy-CC-alkyl, branched CC-alkoxy-CC-alkyl or (R7) R6N-CC- alkyl； R3 is CC-alkyl, branched CC-alkyl, CC-cycloalkyl, -NR6 (R7), -R4, where each alkyl, branched alkyl or cycloalkyl may be optionally substituted with cyano, CC-alkoxy or hydroxy； each R4 is independently and individually selected from the group consisting of and where the symbol (##) represents the attachment point of residue R4； R5 represents oh CC-alkyl, branched CC-alkyl, CC-cycloalkyl or CC-alkoxy-CC-alkyl； each R6 and R7 is individually and independently H, CC-alkyl or branched CC-alkyl； each cycloalkyl and R4 are independently and optionally substituted - (R8)； each R8 individually and independently represents CC-alkyl, branched CC-alkyl, halogen, - (CH) -CN, - (CH) -OR6, - (CH) -NR6 (R7), - ( CH) -SO-CC-alkyl, - (CH) -C (O) NR6 (R7), - (CH) -C (O) -CC-heterocyclyl or - (CH) -CC-heterocyclyl, where each alkyl or alkylene is optionally substituted with one or two CC alkyls； each m is individually and n1. Соединение формулы I:Формула Iили его фармацевтически приемлемая соль, гидрат, сольват, энантиомер, стереоизомер или таутомер, где:X1 представляет собой галоген；X2 представляет собой галоген；Y представляет собой O, -NH；каждый R1 индивидуально и независимо представляет собой галоген, H, C-C-алкил, разветвленный C-C-алкил, C-C-циклоалкил, C-C-алкокси, разветвленный C-C-алкокси или циано；каждый R2 индивидуальн
