Jeyshka M. Reyes Gonzalez;Anil K. Sood;Pablo E. Vivas-Mejia
发明人:
Pablo E. Vivas-Mejia,Jeyshka M. Reyes Gonzalez,Anil K. Sood
申请号：
US15899682
公开号：
US20180185284A1
申请日:
2018.02.20
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention discloses c-MYC-siRNA formulation as a potential therapeutic target for cisplatin-resistant ovarian cancer. It is disclosed targeting c-MYC with small interfering RNA (siRNA) in the cisplatin-resistant ovarian cancer cell line inducing a significant cell growth arrest and inhibition of cell proliferation. Apoptosis and arrest of cell cycle progression were also observed after c-MYC-siRNA-based silencing of c-MYC. Furthermore, delivering nanoliposomal c-MYC-siRNA, decreased tumor weight and number of tumor nodules compared with a liposomal-negative control siRNA.
