Targeting immunological functions to the site of bacterial infections using cell wall targeting domains of bacteriolysins

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专利权人:

INTEGRATED BIOTHERAPEUTICS; INC.

发明人:

Mohammad Javad Aman,Rajan Prasad Adhikari

申请号：

US15111383

公开号：

US10487140B2

申请日:

2015.01.14

申请国别(地区):

US

年份:

2019

代理人:

摘要：

This disclosure provides a comprehensive approach to specifically target various immune functions to the site of infection by a variety of fusion proteins that consist of a bacteriocin cell wall targeting domain (CWT) and an immune function mediating component (IFMC). The CWT targets the fusion protein to the bacterial surface leading to accumulation at the site of infection. The IFMC mediates various immune functions such as toxin neutralization or recruitment of immune cells that can clear the bacteria.

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中国工程科技知识中心

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http://www.ckcest.cn/home/