JUN NIIJIMA,SHINYA ABE,KAZUHIRO YOSHIZAWA,YUKI KOSAKA
申请号：
BRPI0821689
公开号：
BRPI0821689A2
申请日:
2008.12.25
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
It is an object of the present invention to provide an efficient method for manufacturing heterocycle-substituted pyridine derivatives. The present invention provides a method for manufacturing a compound represented by the following formula (I): the method including reacting a compound represented by the following formula (III): and a compound represented by the following formula (II): in a solvent and in the presence of a palladium catalyst and a base, wherein R 1 represents a hydrogen atom, etc.； R 2 represents a hydrogen atom, a C 1-6 alkyl group, an amino group that may be protected with a protective group, etc.； one of X and Y represents a nitrogen atom and the other represents a nitrogen atom or an oxygen atom； Q represents a leaving group； the ring A represents a 5- or 6-member heteroaryl ring or a benzene ring, which may have one or two halogen atoms or C 1-6 alkyl groups； Z represents a single bond, a methylene group, an ethylene group, an oxygen atom, etc.； R represents a hydrogen atom or a C 1-6 alkyl group, etc.； R 3 represents a hydrogen atom or a halogen atom, etc.； and R 4 represents a hydrogen atom or a halogen atom； provided that when Z represents a single bond, or when R 3 represents a hydrogen atom, then R 1 , R 2 , and R 4 cannot all be a hydrogen atom at the same time.
