ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人:
PAPAS, KLEARCHOS K.
申请号：
CA3039653
公开号：
CA3039653A1
申请日:
2017.10.05
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Methods, systems, and devices for enhancing cancer immunotherapy featuring co- transplantation of encapsulated xenogeneic cells with separately encapsulated autologous or allogeneic ceils, e.g., autologous or allogeneic tumor ceils. For example, both a first cellular transplantation device housing a patient's own tumor ceils and a second ceilular transplantation device housing xenogeneic cells may be implanted into a patient. The presence of the xenogeneic ceils elicits an enhanced immune response, e.g., the xenogeneic cells will draw in a large number of immune ceils. Shed tumor antigens from the first cellular transplantation may then be taken up by the immune ceils that were drawn to the xenogeneic cells. This will generate an anti-tumor immune response that is amplified relative to a response elicited by the encapsulated tumor cells alone.
