The Regents of the University of California; a California corporation
发明人:
Karl Y. Hostetler,James R. Beadle,Nadejda Valiaeva
申请号：
US14499865
公开号：
US09475832B2
申请日:
2014.09.29
申请国别(地区):
US
年份:
2016
代理人:
摘要：
There are provided, inter alia, acyclic nucleoside phosphonate compounds having reduced toxicity and enhanced antiviral activity, and pharmaceutically accepted salts and solvates thereof. There are also provided methods of using the disclosed compounds for inhibiting viral RNA-dependent RNA polymerase, inhibiting viral reverse transcriptase, inhibiting replication of virus, including hepatitis C virus or a human retrovirus, and treating a subject infected with a virus, including hepatitis C virus or a human retrovirus.
