Momotaro-Gene Inc.;National University Corporation Okayama University;Industry-University Cooperation Foundation Hanyang University
发明人:
Hiromi KUMON,Yasutomo NASU,Masami WATANABE,Chae Ok YUN
申请号：
US15313674
公开号：
US20170202892A1
申请日:
2015.05.26
申请国别(地区):
US
年份:
2017
代理人:
摘要：
An object of the present invention is to provide a conditionally replicating adenovirus having a strong anticancer effect. A conditionally replicating adenovirus to replicate specifically in a cancer cell and express REIC protein or REIC C domain protein, wherein the conditionally replicating adenovirus is obtained by inserting full-length REIC DNA or REIC C domain DNA into a conditionally replicating adenovirus comprising an ITR (inverted terminal repeat) sequence of an adenovirus type 5 genome and insertion of an HRE sequence, an hTERT promoter, a decorin-encoding DNA, and a DNA encoding a peptide comprising an RGD sequence.
