< Topic >In detail, as the material which suppresses the activity of L1CAM shisupurachin and gemushitabin (gemcitabine), is something regarding the constituent for the anticancer which features that the material which is chosen from 5 fluorouracil and the taxol is included as an oligonucleotide, and the anticancer agent which suppress the invention of L1CAM the unique anti- L1CAM antibody, as the material which suppresses the revelation of L1CAM in L1CAM this invention, in regard to the constituent for the anticancer which includes the material and the anticancer agent which suppress the activity or revelation of L1CAM.SolutionsThe constituent by this invention although being powerful much independently treated in comparison with the respective pharmacology effect which by simultaneously, or, consecutively jointly using, the material and the anticancer agent which suppress the activity or revelation of L1CAM which is included in that individually, these materials showing the significant cancer cell growth and the extinction effect, is very useful in remedy of the cancer.< Choice figure >Drawing 2【課題】本発明は、L1CAMの活性または発現を抑制する物質および抗癌剤を含む抗癌用組成物に関し、より詳細には、L1CAMの活性を抑制する物質としてL1CAMに特異的な抗L1CAM抗体、L1CAMの発現を抑制する物質としてL1CAMの発明を抑制するオリゴヌクレオチド、および抗癌剤としてシスプラチン、ゲムシタビン(gemcitabine)、5-フルオロウラシルおよびタキソールから選択される物質を含むことを特徴とする抗癌用組成物に関するものである。【解決手段】本発明による組成物は、それに含まれるL1CAMの活性または発現を抑制する物質および抗癌剤を同時に、個別にまたは、順次に併用することによって、これらの物質単独で処理したそれぞれの薬理学的効果に比べてはるかに強力でありながら有意的な癌細胞成長および死滅効果を示して、癌の治療に非常に有用である。【選択図】図2
