The present invention relates to the use of an antisecretory protein or a derivative, homologue,and/or fragment thereof, having antisecretory activity, and/or a pharmaceuticallyactive salt thereof, for the manufacture of a pharmaceutical composition and/ora medical food for the treatment and/or prevention of compartment syndrome.A compartment syndrome may be caused by or a cause of a variety of other conditionswhich are also encompassed by the present invention, such as viral and bacterialinfections. Furthermore, the invention relates to a method for the treatmentand/or prevention of compartment syndrome in a mammal in need thereof.