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Engineered Tissue Implants And Methods Of Use Thereof
专利权人:
Jian LING
发明人:
Jian LING
申请号:
US13194348
公开号:
US20130030548A1
申请日:
2011.07.29
申请国别(地区):
US
年份:
2013
代理人:
摘要:
A engineered tissue implant comprising a perfusion chamber formed with a biocompatible flexible tubular member having a wall defining an internal fluid flow passage and a porous scaffold within the fluid flow passage of the tubular member, the porous scaffold arranged such that, in a presence of a perfusion fluid, the perfusion fluid will flow through the porous scaffold and be inhibited from flow between the porous scaffold and the wall of the tubular member. The engineered tissue implant may be understood as a transplantable cell construct or as an implantable bioreactor for cell growth both in vitro and/or in vivo. A method to provide tissue for reconstruction may comprise forming the engineered tissue implant containing a scaffold, introducing and seeding cells to the scaffold, introducing a perfusion fluid to the scaffold which flows through the fluid flow passage and scaffold, proliferating the cells within the scaffold and forming blood vessels within the scaffold. This may be followed by transplanting the engineered tissue implant in vivo where nutrition and oxygen are provided to support the preloaded cells.
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