Use of FGFR1 extra cellular domain proteins to treat cancers characterized by ligand-dependent activating mutations in FGFR2

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专利权人:

Five Prime Therapeutics; Inc.

发明人:

Harding, Thomas,Kavanaugh, Michael W.

申请号：

AU2010319327

公开号：

AU2010319327A1

申请日:

2010.11.12

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

The present invention relates to the use of Fibroblast Growth Factor Receptor I (FGFR1) extracellular domain (ECD) polypeptides for treatment of cancers characterized by ligand dependent activating mutations in Fibroblast Growth Factor Receptor 2 (FGFR2). For example, the present invention relates to the treatment of endometrial cancers and other cancers wherein tumor cells express FGFR2 mutants in the IgII-IgIII hinge region or IgIII domain of the protein, such as at amino acid positions 252 and/or 253.

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