Mayo Foundation for Medical Education and Research
发明人:
Kirkland James L.,Tchkonia Tamar,van Deursen Jan M. A.,Baker Darren J.
申请号：
US201514792208
公开号：
US9968076(B2)
申请日:
2015.07.06
申请国别(地区):
美国
年份:
2018
代理人:
Fish & Richardson P.C.
摘要：
This document provides a transgenic mouse for studying the role of senescent cells in an age-related phenotype. A recombinant polypeptide is expressed in senescent cells under control of a p16INK4a promoter. The polypeptide can be triggered to directly induce cell death in senescent cells. As a result, progression of one or more age-related phenotypes is delayed in the mouse. An example is the INK-ATTAC mouse which also expresses a marker polypeptide in senescent cells.
