Klaus Langer,Matthias Wacker,Beate Röder,Annegret Preuss,Volker Albrecht,Susanna Gräfe,Arno Wiehe,Hagen von Briesen,Karin Löw,Sylvia Wagner
申请号：
US12941350
公开号：
US09211283B2
申请日:
2010.11.08
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Compositions, which are stable in storage, and a method of production of pharmaceutical based nanoparticulate formulations for photodynamic therapy comprising a hydrophobic photosensitizer, human serum albumin (HSA) and stabilizing agent are provided. These nanoparticulate formulations provide therapeutically effective amounts of photosensitizer (PS) for parenteral administration. In particular, tetrapyrrole derivatives can be used as photosensitizers whose efficacy and safety are enhanced by such nanoparticulate formulations. A method of preparing the HSA-based nanoparticles under sterile conditions is also provided. In one of the preferred embodiments of the present invention temoporfin, a hydrophobic PS, is formulated as a nanoparticle for parenteral administration. The formulations are useful for treating hyperplasic and neoplasic conditions, inflammatory problems, and more specifically to target tumor cells.
