The present invention relates to an immunogenic composition comprising one ormore C. difficile toxoid for use in amedicament for animals. The invention also encompasses an immunogeniccomposition comprising one or more C. difficile A toxoid andone or more C. difficile B toxoid and one or more C. perfringens Type Atoxoid. The invention also encompasses vaccines comprisingsaid immunogenic compositions, vaccines for use in the treatment and/orprevention of disease caused by C. difficile and C. perfringens,and kits thereof.