KIM, SUN-OK,KIM, SANG-HEE,CHO, EUN-AH,IN, CHANG-HOON
申请号：
CA2823138
公开号：
CA2823138A1
申请日:
2011.12.29
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
Disclosed are small interfering RNA (siRNA) that complementarily binds to a base sequence of Hif1a mRNA transcript, thereby inhibiting expression of Hif1a without inducing immune responses, and a use of the siRNA for prevention and/or treatment of cancer. Since Hif1a is commonly overexpressed in almost all cancer cells, the siRNA that complementarily binds to Hif1a-encoding mRNA may inhibit expression of Hif1a through RNA-mediated interference (RNAi), thereby inhibiting proliferation and metastasis of cancer cells, and thus, the siRNA may be useful as an anticancer agent.
