The present invention provides combination vaccines that comprise an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis, and one or more immunological active components effective in treatment and/or prophylaxis of two further disease-causing organisms for swine being Mycobacteria hyopneumoniae and Porcine circovirus. Moreover, the present invention also relates to a kit that comprises an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis, and one or more immunological active components effective in treatment and/or prophylaxis of at two further disease-causing organism for swine being Mycobacteria hyopneumoniae and Porcine circovirus.
