Alan S. WAYNE,Ira Pastan,Karen Kaucic,Robert Lechleider
申请号：
US13207856
公开号：
US20120177567A1
申请日:
2011.08.11
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides methods for the treatment of acute lymphoblastic leukemia (ALL) in pediatric patients using an anti-CD22 immunotoxin. The methods disclosed comprise administering to a pediatric patient in need of that treatment an effective dose of a recombinant immunotoxin comprising a variable light (VL) chain linked to a variable heavy (VH) which is genetically fused to a therapeutic moiety comprising a Pseudomonas exotoxin A PE38 fragment. The recombinant immunotoxin specifically binds CD22 thereby inhibiting the growth of CD22-expressing (CD22+) ALL cancer cells.
