JOSHI, PRAMOD,KRENITSKY, PAUL,GONZALEZ, JESUS,WANG, JIAN,WILSON, DEAN,TERMIN, ANDREAS
申请号：
NZ59641307
公开号：
NZ596413A
申请日:
2007.04.11
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
ABSTRACT - 596413 The disclosure relates to phenylsulfinyl-3-sulfamoylphenyl-benzamide compounds of formula (I), which are useful as inhibitors of voltage-gated sodium channels, wherein the variables are as defined in the specification. The disclosure also provides pharmaceutically acceptable compositions comprising said compounds and their use for treating or lessening the severity in a subject of acute, chronic, neuropathic, or inflammatory pain, arthritis, migraine, cluster headaches, epilepsy, neurodegenerative disorders, psychiatric disorders, anxiety, depression, dipolar disorder, myotonia, arrhythmia, movement disorders, neuroendocrine disorders, ataxia, multiple sclerosis, irritable bowel syndrome, incontinence, visceral pain, osteoarthritis pain, back pain, head pain, neck pain, severe pain, intractable pain, nociceptive pain, breakthrough pain, postsurgical pain, cancer pain, stroke, cerebral ischemia, traumatic brain injury, amyotrophic lateral sclerosis, stress-induced angina, exercise induced angina, palpitations, hypertension, migraine, or abnormal gastro-intestinal motility.
