N-[2-(1 -BENZYLPIPERIDIN-4-YL)ETHYL]-4-(PYRAZIN-2-YL)-PIPERAZINE-1 -CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MUSCARINIC RECEPTOR 4 (M4) ANTAGONISTS FOR TREATING NEUROLOGICAL DISEASES
Provided herein are small molecule compounds of the following formula (I): or a stereoisomer, tautomer, solvate, ester, prodrug, or pharmaceutically acceptable salt thereof, wherein A, B, C, L<；sub>；1<；/sub>；, L<；sub>；2<；/sub>；, R<；sub>；1<；/sub>；, R<；sub>；2<；/sub>；, R<；sub>；3<；/sub>；, R<；sub>；4<；/sub>；, R<；sub>；s<；/sub>；, w, x, y and z are as defined herein. Methods for treating diseases/disorders by antagonizing muscarinic receptors, including specifically antagonizing muscarinic receptor 4 (M4), are also provided.
