YOON, DAVID S.,ANUMULA, RUSHITH KUMAR,CHERUKU, SRINIVAS,HUANG, YANTING,JURICA, ELIZABETH ANNE,MENG, WEI,NARA, SUSHEEL JETHANAND,NARAYAN, RISHIKESH,SISTLA, RAMESH KUMAR,WU, XIMAO,ZHAO, GUOHUA
申请号：
CA3079833
公开号：
CA3079833A1
申请日:
2018.10.31
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention provides compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds modulate the activity of farnesoid X receptor (FXR), for example, as agonists. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
