Methods of the present disclosure utilize alcohol (e.g., ethanol) as an active ingredient or agent for disinfecting, washing, and/or treating infection in the upper and/or lower airways. Methods include aerosol inhalation, lung spraying, and/or lung lavage using ethanol-containing solutions. Such methods can be applied to complicated pneumonia and respiratory pandemics, including the COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).