Anti-fall safety system intended to prevent the detachment of a first component with respect to a second component of an opening and closing system, wherein the first component and the second component are constrained to each other by means of reciprocal retaining means, in such a way that the first component is mobile with respect to the second component, said safety system comprising an at least partially flexible elongated means which is provided with at least one engagement element placed in correspondence of one end of said elongated means, said engagement element being intended to engage in correspondence of an engagement point, following said engagement the elongated means preventing the detachment of the first component with respect to the second component.