THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人:
TENENBAUM, SCOTT, A.,DOYLE, FRANCIS, JOSEPH, II.,GEORGE, AJISH,ZALESKI, CHRISTOPHER
申请号：
EP10778508
公开号：
EP2432794A4
申请日:
2010.05.21
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
Disclosed are RNA constructs which function to activate or inactivate a biological process, e.g., may be designed for attachment to a polypeptide coding region. Such RNA constructs modulate translation of a polypeptide from the coding region in response to the presence of a target polynucleotide in an expression environment. Such RNA constructs include a weakened stem-loop structure which, when bound to the target polynucleotide, assumes stem-loop secondary structure and associates with an RNA binding protein. Association with the RNA binding protein modulates translation of the polypeptide coding region. Such RNA constructs also have three-way junction joining regions 3&prime and 5&prime of the stem-loop structure.
