[Problems] The object of the present invention is to provide a Medical Drugs which reduce damage of gastrointestinal mucosal induced by NSAIDs. [Means for Solving Problems] The Medical Drugs that comprises a mixture of NSAIDs and sugar that reduce damage of gastrointestinal mucosal induced by NSAIDs is already known. However the mixture is not enough to suppress damage of gastrointestinal mucosal. The inventors invented new molecular compounds with NSAIDs and trehalose. The new molecular compounds effectively reduce damage of gastrointestinal mucosal induced by NSAIDs.