Disclosed is an isolated antibody, or one of its derivative compounds or functional fragments, capable of binding to the CD151 protein and of inhibiting tumour growth in vivo, comprising a heavy chain and a light chain, each of these chains comprising 3 CDRs, respectively, wherein said isolated antibody, or one of its derivative compounds or functional fragments, comprises, among its 6 CDRs, at least three CDRs selected from the CDRs of sequence SEQ ID No. 1-6, 17-22, 33-35, 43-48, 59-63, 69-73, 79-81 or 85-89 or at least three CDRs whose sequence has at least 80% identity, after optimal alignment, with the sequences SEQ ID No. 1-6, 17-22,33- 35, 43-48, 59-63,69-73, 79-81 or 85-89.
