An oral cancer screening device (10) used for the detection of pre-cancerous and cancerous tissue has a power supply (100), an illumination source (200), a selector switch (300) that enables the activation of a specific wavelength of light from the illumination source (200), an electrical system (400) in communication with the selector switch (300) and the illumination source (200), a heat sink (500) in thermal communication with the illumination source, a filter or cover (600) to protect the illumination source, and a transparent sheath (700) for providing a sanitary shield for the device when it is brought into contact or close proximity with the patient oral cavity. The sheath may optionally have an angled mirror incorporated at a distal end of the sheath to provide the operator with a reflected image of the illuminated tissue (900). The operator will optionally utilize head mounted lenses (800) to assist the operators visualization of the light from the illuminated oral cavity.