The invention provides an adjustable means for supporting the breast from beneath the nipple during a prone breast biopsy procedure. By increasing or decreasing the volume of air or fluid within the pillow, the clinician can apply a controlled amount of compression on the breast, thereby increasing or decreasing the compressed area of the breast. The invention is believed to have utility for all modalities of breast biopsy however, it is believed to be especially useful for a prone MRI breast biopsy procedure.