PROBLEM TO BE SOLVED: To provide an agent for the prophylaxis, improvement or therapy of intractable inflammatory bowel disease.SOLUTION: The present invention provides an agent for the prophylaxis, improvement or therapy of intractable inflammatory bowel disease, the agent comprising an anti-CD81 antibody as an active ingredient.COPYRIGHT: (C)2016,JPO&INPIT【課題】難治性の炎症性腸疾患の予防、改善または治療用薬剤の提供。【解決手段】抗CD81抗体を有効成分として含む、難治性の炎症性腸疾患の予防、改善または治療用薬剤。【選択図】なし