Offer of the caverage antibody which is obtained by the production manner, and the said manner of the caverage antibody for the whole protein which is revealed on the surface of the microbe. (A) The manner which produces the caverage antibody which includes the antibody for numerator the whole protein where it locks the protein which has been revealed on the surface of the aforementioned microbe by treating the microbe with the protein building a bridge fixed reagent, with building a bridge inside the numerator, it prescribes to the animal (b) the aforementioned microbe which is locked with the said protein building a bridge fixed reagent as a immunogen, (includes the fact that the antibody is obtained from c) animal, reveals on the surface of the microbe.微生物の表面に発現するタンパク質全体に対する網羅的抗体の作製方法、及び該方法により得られた網羅的抗体の提供。(a)微生物をタンパク質架橋固定試薬で処理することにより、前記微生物の表面に発現しているタンパク質を分子内架橋により固定し、(b)該タンパク質架橋固定試薬で固定した前記微生物を免疫原として動物に投与し、(c)動物から抗体を得ることを含む、微生物の表面に発現するタンパク質分子全体に対する抗体を含む網羅的抗体を作製する方法。
