A compound of formula (I) in which R0 is selected from the group consisting of hydrogen and 3-chlorophenylcarbonyl-； each of R1 and R2 is methyl； alternatively, R1 and R2 are taken together with the carbon atom to which they are attached to form 4- (tetrahydrothiopyran-1,1-dioxide)； R3 is selected from the group consisting of hydrogen and chlorine； X is CR410； R4 is selected from the group consisting of phenylsulfonyl-, 4-methoxyphenyl-sulfonyl-, 3-fluorophenyl-sulfonyl-, 4- chlorophenyl-sulfonyl-, diethylamino-sulfonyl-, and 1-piperidinyl-sulfonyl, a is 0； R5 is selected from the group consisting of 3-chlorophenyl, 2- (2-aza-spiro [4,5] decan-3-one), 2-imidazolyl, 3- (1- phenyl-imidazolyl), 1- ( 2-phenyl-imidazolyl), 1- (2-phenyl-4-methyl-imidazolyl), 1- (2- (4-chlorophenyl) -imidazolyl), 1- (5- (4- chlorophenyl) -imidazolyl), 1 - (5- (4-chlorophenyl) -pyrazolyl), 3- (1- (4-chlorophenyl) -pyrazolyl), 2- (1-phenyl-2-pyrazolin-3-one), 3- (1- phenyl- 4,5-dihydro-pyrazolyl), 2- (1- (4-chlorophenyl) -1,2-dihydro-pyrazol-3-one), 1- (2-phenyl-2,5-dihydro-pyrazol-5- one), 3- (6- phenyl-pyridazinyl), 3- (6- (4-chlorophenyl) -pyridazinyl), 1- (3- (4-chlorophenyl) -pyridazin-6-one), 2- (4- trifluoromethyl-pyrimidinyl), 2- (4,5-dihydro-oxazolyl), 1- (4- (4-fluorophenyl) -piperidinyl), 1- (4- (4-chlorophenyl) -piperidinyl), 1- (4- (4-nitrophenyl) -piperidinyl), 2- (pyrrolo [3,4-c] pyridine-1,3-dione), 4-quinazolinyl, 4- (2-amino-quinolinyl), 1- (3,4- dihydro-isoquinolinyl), 2- (quinazolin-4-one), 2- (6-chloro-3H-quinazolin-4-one), 1- (5-chloro-indolin-2,3-dione), 2- ( 5-chloro-1,3-dioxo-isoindolyl), 1- (3-aminoi ndazolyl), 1- (3-amino-4-fluoro-indazolyl), 1- (3-amino-5-bromo-indazolyl), 2- (3-amino-5-chloro-indazolyl), 2- (5- chlorobenzthiazolyl), 2- (5-fluoro-benzthiazolyl), 2- (5-ethoxy-benzthiazolyl), 2- (5-nitro-benzthiazolyl), 3- (6-nitro-benzthiazolyl), 3- (benzothioazolyl), 2 - (benzo [d] isothiazol-3-one), 2- (5-chloro-benzoxazolyl), 3-bencisoxazolyl, 3- (5-chloro benci
