The invention relates to a sphygmomanometer with interchangeable configuration to be adapted for use by a right hand or a left hand, comprising, in a mano-pear (MP): - an inflation bulb (3) of a cuff, - a manometer (2) for reading the arterial pressure, - a connection member (710) adapted to receive the end (41) of a flexible tubular cord (4) connected to the cuff, - a deflation valve (7) cuff installed in a terminal block (5), - a control device (90) of the valve (7) associated with said valve, - a terminal block (5) adapted to ensure fluid communication between the inflation bulb (3), the pressure gauge (2), the valve (7) and the connecting member (710), - this mano-pear having a sagittal median plane and, with respect to this sagittal plane: a right side (D) and a left-hand side (G), characterized in that the valve (7), the control device (90) and the connecting member (710) are combined into a unitary assembly, which assembly is removably and removably installed in a mano-pear arrangement so that said control device (90), respectively said connecting member (710), can be arranged indifferently on the right side (D) or the left side (G) of the mano-pear according to whether the sphygmomanometer is used by a right hand or a left hand. L'invention concerne un sphygmomanomètre à configuration interchangeable pour être adaptée à son utilisation par une main droite ou une main gauche, comprenant, réunis en un mano-poire (MP) : - une poire de gonflage (3) d'un brassard, - un manomètre (2) de lecture de la pression artérielle, - un organe de connexion (710) adapté pour recevoir l'extrémité (41) d'un cordon tubulaire souple (4) relié au brassard, - une soupape (7) de dégonflage du brassard installée dans un bloc de jonction (5), - un dispositif de commande (90) de la soupape (7) associé à ladite soupape, - un bloc de jonction (5) adapté pour assurer une communication fluidique entre la poire de gonflage (3),