CHUNG, HAE YOUNG,정해영,MOON, HYUNG RYONG,문형룡,LEE, HYE JIN,이혜진,PARK, JI YOUNG,박지영,PARK, YUN JUNG,박윤정,PARK, JIN NAM,박진남,PARK, JUNE WHAN,박준환,JUNG, YU RI,정유리,AN, HYE JIN,안혜진
申请号：
KR1020130013616
公开号：
KR1012924780000B1
申请日:
2013.02.06
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A novel compound with whitening effect and peroxisome proliferator-activated receptor (PPAR) activity is provided to ensure skin whitening activity by suppressing tyrosinase, and to be used in a pharmaceutical composition or a cosmetic product for skin whitening, and as a pharmaceutical composition or a health functional food for preventing and treating obesity, metabolic diseases, or cardiovascular diseases.CONSTITUTION: A compound is denoted by chemical formula 1. A skin whitening composition contains the compound of chemical formula 1 as an active ingredient. The compound is selected from the group consisting of 2- (2,4-dihydroxyphenyl)-5,6- (methylenedioxy)-benzothiazole, 2- (3-methoxy-4-hydroxyphenyl)-5,6- (methylenedioxy)-benzothiazole, 4- (6,7-dihydro-5H-indeno&lsqb5,6-d&rsqbthiazol-2-yl)benzene-1,3-diol, 5- (6,7-dihydro-5H-indeno&lsqb5,6-d&rsqbthiazol-2-yl)-2-methoxyphenol, and bromo-4- (6,7-dihydro-5H-indeno&lsqb5,6-d&rsqbthiazol-2-yl)phenol. A pharmaceutical composition for preventing or treating one disease selected among obesity, metabolic diseases, and cardiovascular diseases contains the compound of chemical formula 1 as an active ingredient, and is regulated by PPAR activity. The PPAR is PPAR alpha or PPAR gamma.COPYRIGHT KIPO 2013본 발명은 피부미백 및 PPAR 활성을 갖는 신규 화합물 및 이의 의학적 용도에 관한 것으로, 본 발명에 따른 화합물들은 티로시나아제를 억제하는 피부미백 활성을 지니므로 피부미백용 약학조성물 또는 화장품에 유용하게 사용될 수 있고, 또한 PPAR 활성 특히, PPARα 및 PPARγ 활성을 지니므로 비만, 대사성 질환 또는 심혈관계 질환을 예방하고 치료하는 데에 유용한 약학조성물 또는 건강기능식품으로 사용될 수 있다.
