A medical device for sealing and repairing defects in a body lumen wall includes a wire frame and a partially-circumferential stent body. In some embodiments, the endolumenal sealing devices provided herein are well-suited for use in the GI tract including the colon. That is the case because the partially-circumferential sealing devices are configured to be compliant with the peristaltic movements of the GI tract. This feature can enable the sealing devices to resiliently remain located in a desired position within the GI tract, such that the defect in the lumen wall is sealed by the presence of the sealing device.
