Invention provides a compound of formula, (I): [Formula 1] In the formula, represents a group = N-OH or X represents an oxygen atom R [2] of B is a hydrogen atom, taken together with A or hydroxyl - shows carbon bond shows carbon bonds - A carbon taken together with B or a hydrogen atom C, D, E represents a group selected from F and carbon atoms which together with D hydrogen atom or - indicates the carbon bond. ] For one of the acid addition salts thereof or a pharmaceutically acceptable compounds, represented by. However, I except for some compounds. Medicament, the present invention relates to the use as a neuroprotective agent in particular. The present invention also relates to pharmaceutical compositions and novel compounds having the general formula (I).本発明は、式(I):【化1】[式中、Xは酸素原子又は=N-OH基を示し;Rは【化2】から選ばれる基を示し;Aは水素原子又はBと一緒になって炭素-炭素結合を示し;Bは水素原子、水酸基又はAと一緒になって炭素-炭素結合を示し;C、D、E及びFは水素原子又はDと一緒になって炭素-炭素結合を示す。]で表される化合物、又は薬学的に許容されるそれらの酸付加塩の1つに関する。但し、いくつかの化合物を除く。本発明は、医薬、特に神経保護因子としての使用に関する。本発明はまた、一般式(I)を有する新規化合物及び医薬組成物に関する。
