ПУРОХИТ Аджай (US),БЕНИТЕС Педро (US),ЧИЗМАН Эдвард Х. (US),ЛАЗЕВАЦКИ Джоэл (US),ЛИ Вероника (US),ЧЕЗАТИ Ричард Р. III (US),ЛУБИ Ричард (US),РАДЕКЕ Хайке С. (US)
申请号：
RU2012153210/04
公开号：
RU2012153210A
申请日:
2011.05.11
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. Salt characterized by the formula (VII): where X is an ascorbate. 2. Salt characterized by formula (VI): where X is a formate. 3. The salt of claim 1 or 2, wherein the fluorine is isotopically enriched in F. 4. A pharmaceutically acceptable composition comprising a salt according to any one of claims. 1-3 and optionally a pharmaceutically acceptable excipient. 5. A method for visualizing a subject, comprising: administering to the subject a dose of a pharmaceutically acceptable composition comprising a salt according to claims 1-3, where fluorine is optionally isotopically enriched in F, and optionally a pharmaceutically acceptable excipient； and obtaining at least one image of a portion of the subject. 6. The method of claim 5, wherein the maximum salt dose is about 13 mCi or less. The use of salt according to any one of paragraphs. 1-3 to visualize parts of the subject. 8. A composition comprising a compound of formula (II): or a salt thereof, a free base, or a combination thereof, wherein: R is alkyl, haloalkyl, alkynyl, alkenyl, heteroalkyl, cycloalkyl, aryl, heteroaryl, arylalkyl, heterocyclyl or heteroarylalkyl, each optionally substituted； each R may be the same or different and represents hydrogen or a nitrogen protecting group； R, R, R and R may be the same or different and individually represent hydrogen, CC-alkyl, heteroalkyl, halide, -OR, -SR, -N (R) or -C (= O) R, moreover, each is optionally substituted； each R may be the same or different and represents hydrogen, alkyl, heteroalkyl, cycloalkyl, heterocyclyl, haloalkyl, aryl or heteroaryl, and each is optionally substituted； each R may be the same or different and represents hydrogen, alkyl, heteroalkyl, cycloalk1. Соль, характеризующаяся формулой (VII):где Xявляется аскорбатом.2. Соль, характеризующаяся формулой (VI):где Xявляется формиатом.3. Соль по п. 1 или 2, где фтор изотопно обогащенF.4. Фармацевтически приемлемая композиция, содержащая соль по любому из пп. 1-3 и необязательно фармацевтическ
