The present disclosure relates to milk-based nutritional compositions comprising lactoferrin and/or a prebiotic component, wherein, when combined, the lactoferrin and prebiotic component may exhibit additive or synergistic beneficial effects on the health and development of a pediatric subject. The disclosure further relates to methods comprising the administration of said milk-based nutritional compositions to pediatric subjects.本揭露內容關於以乳為底質之營養組成物,其包含乳鐵蛋白及/或益菌素組分,其中當結合時,該乳鐵蛋白和益菌素組分對兒科個體之健康和發育可顯現出加成或協同之有益效果。本揭露內容進一步關於包含投予兒科個體該以乳為底質之營養組成物的方法。