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YEAST-BASED IMMUNOTHERAPY AGAINST CLOSTRIDIUM DIFFICILE INFECTION
专利权人:
Hanping FENG
发明人:
Hanping FENG,James Eugene GALEN,Kevin CHEN,Yixuan ZHU
申请号:
US15768331
公开号:
US20180319872A1
申请日:
2016.10.13
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Antibody-based binding agents derived from human and camelid immunoglobulins are described, as well as strains of yeast engineered to secrete the binding agents, and methods of treating and preventing Clostridium difficile infections using the engineered strains of yeast. These binding agents recognize and bind with specificity to Clostridium difficile toxin A and/or toxin B and in some cases exhibit toxin neutralizing activity. The binding agents include camelid VHH peptide monomers, linked groups of VHH peptide monomers, VHH peptide monomers joined to antibody Fc domains, and VHH peptide monomers joined to IgG antibodies.
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