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INACTIVATED MYCOBACTERIA FOR ORAL USE IN PREVENTION OF TUBERCULOSIS
专利权人:
ФУНДАСИО ИНСТИТУТ ПЕР А ЛА ИНВЕСТИГАСИО ЭН СЬЕНСЬЕС ДЕ ЛА САЛУТ "ХЕРМАНС ТРИАС И ПУХОЛЬ" (ИГТП) (ES);СИБЕР ДЕ ЭНФЕРМЕДАДЕС РЕСПИРАТОРИАС (СИБЕРЕС) (ES)
发明人:
КАРДОНА ИГЛЕСИАС Пере-Хоан (ES),ВИЛАПЛАНА МАССАХЕР Кристина (ES),МАРСО ЭСКАРТИН Элена (ES)
申请号:
RU2015101114
公开号:
RU2015101114A
申请日:
2013.06.13
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. The use of inactivated mycobacteria for the preparation of a drug for the prevention of tuberculosis, in which mycobacteria are periodically administered orally, the interval between doses does not exceed 5 days, and the number of doses administered is at least 5.2. The use according to claim 1, wherein the inactivated mycobacteria are selected from the group consisting of M. tuberculosis, M. Bovis, M. africanum and M. microti, M. bovis BCG, M. fortuitum, and M. kansasii. 3. The use of claim 2, wherein the inactivated mycobacteria are selected from M. tuberculosis, M. Bovis, M. bovis BCG, M. fortuitum, and M. kansasii. 4. The use according to any one of paragraphs. 1-3, where the mycobacteria are inactivated by the heating process. 5. The use according to any one of paragraphs. 1-3, where the interval between doses is not more than 3 days. 6. The use according to claim 5, where the interval between doses is not more than 2 days. The use according to any one of paragraphs. 1-3, where the number of doses administered is at least 7.8. The use of claim 7, wherein the number of doses administered is at least 9.9. The use according to any one of paragraphs. 1-3, where each dose contains between 10 and 10 inactivated mycobacteria. 10. The use according to any one of paragraphs. 1-3, where the mycobacteria is administered in the form of a pharmaceutical composition containing inactivated mycobacteria and at least one pharmaceutically acceptable excipient. 11. The use of claim 10, wherein the pharmaceutical composition is in the form of capsules. The use of claim 11, wherein the pharmaceutical preparation is in the form of tablets. The use according to any one of paragraphs. 1-3, where it is administered to an individual infected with M. Tuberculosis, in whom the infection is latent. 14. The use of claim 13, wherein the individual has developed an active form of tuberculosis in the past. The use according to any one of paragraphs. 1-3, where it is administered to an indiv
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