WAGENINGEN UNIVERSITEIT;ACADEMISCH MEDISCH CENTRUM
发明人:
MAX NIEUWDORP,WILLEM MEINDERT DE VOS
申请号：
BR112017003778
公开号：
BR112017003778A2
申请日:
2015.08.28
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The present invention therefore relates to a compound effective against ralstonia pickettii for use in the treatment or prevention of insulin resistance, obesity or type ii diabetes of an individual. preferably said compound is selected from the group consisting of an effective antibiotic against ralstonia pickettii, an immunogenic compound capable of producing a protective immune response in an individual and an antibody that specifically binds ralstonia pickettii or a binding fragment thereof. The invention further relates to an in vitro method of diagnosing or predicting insulin resistance, obesity or type II diabetes in an individual comprising determining the presence of ralstonia pickettii or the presence of an antibody that specifically binds ralstonia pickettii in a test sample of said individual. In another aspect, the invention provides the use of an antibody that specifically binds a ralstonia pickettii antigen, a ralstonia pickettii cell and / or a nucleic acid that hybridizes under stringent conditions to a ralstonia pickettii nucleic acid in a method according to the invention. with the invention. The invention further provides the use of a kit comprising said antibody, a nucleic acid as defined above and optionally comprising a ralstonia pickettii bacterium or a nucleic acid or protein thereof, an additional reagent or a conventional kit component.a presente invenção refere-se, portanto, a um composto eficaz contra ralstonia pickettii para o uso no tratamento ou prevenção de resistência à insulina, obesidade ou diabetes tipo ii de um indivíduo. preferivelmente, o dito composto é selecionado do grupo que consiste em um antibiótico eficaz contra ralstonia pickettii, um composto imunogênico capaz de produzir uma resposta imune protetora em um indivíduo e um anticorpo que se liga especificamente a ralstonia pickettii ou um fragmento de ligação da mesma. a invenção se refere ainda a um método in vitro de diagnóstico ou previsão de resistência à insulina, o
