Disclosed herein are methods for reducing or arresting an increase in a Neuropathy Impairment Score (NIS) or a modified NIS (mNIS+7) in a human subject by administering an effective amount of a transthyretin (TTR)-inhibiting composition.本文中揭示藉由投與有效量之甲狀腺素運載蛋白(TTR)抑制性組合物來降低或遏制人類個體之神經病變性損傷分數(NIS)或修改版NIS(mNIS+7)升高的方法。