WRIGHT JEREMY C,TAMRAZ WILMA,LEONARD JOHN J,GIBSON JOHN W,BRANHAM KEITH E,SJOBECK STEFANIA,BOYD BROOKS,RUBINO CHRISTOPHER M
申请号：
IN8192/DELNP/2015
公开号：
IN2015DN08192A
申请日:
2015.09.10
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
A carrier formulation for controlled release of injectable drugs is disclosed. The formulation comprises a pharmaceutical active agent a high viscosity liquid carrier material (HVLCM) like sucrose acetate isobutyrate a lactic acid based polymer like poly(lactic acid)(glycolic acid) and an organic solvent which maintains the composition in a monophasic form at 25�C in one atmosphere. The drug is released upon administration such that less than 10% (e.g. 2 8%) of drug is released in the first 5 hours 10% to 80% of the drug is released during a period of 5 hours to 7 days after administration and 10% to 40% of the drug is released gradually over a period of 7 days to 28 days from initial administration. The drug may be an anti schizophrenia agent delivered by injection.
