The present invention relates to a collagen-related polypeptide (CRP) havinghydrophobic amino acid groups atthe N- and C-termini capable of non-covalent self-assembly into collagenmimetic triple helices and fibrils thereof and thesynthesis, methods of use and compositions thereof. The present invention alsorelates to novel hemostatic foam substrates, a method ofmanufacturing the foam substrates, and a method of stimulating hemostasis in amammal using such foam substrates.