PURPOSE: A composition containing a material which induced SIRT1 expression for preventing or treating sepsis or septic shock is provided to reduce pro-inflammatory cytokine and to increase anti-inflammatory cytokine. CONSTITUTION: A pharmaceutical composition for preventing or treating sepsis or septic shock contains a material which induces SIRT1(silent mating type information regulation 2 homolog； Sirtuin1) expression as an active ingredient. The material is interferon beta, cGMP(cyclic guanosine monophosphate), adiponectin, pyruvate, or 2-deoxyglucose. A food composition for preventing or treating sepsis or septic shock contains the material as an active ingredient. The pharmaceutical composition is formulated or co-administered together with anti-inflammatory agent, antipyretic analgesic, anticoagulant, antibiotics, antibacterial agent, and anti-allergic agent.본 발명은 SIRT1(silent mating type information regulation 2 homolog) 발현 유도 물질을 포함하는 패혈증 또는 패혈증 쇼크의 예방 또는 치료용 조성물에 관한 것이다. 본 발명에 따른 SIRT1 발현 유도 물질은 전염증성 사이토카인을 감소시키고, 항염증성 사이토카인을 증가시킴으로써, 패혈증 또는 패혈증 쇼크로 인한 사망률을 현저히 낮출 수 있어 패혈증 또는 패혈증 쇼크의 예방 또는 치료에 유용하게 사용될 수 있다.
