This Hair is bright provide can Enough molecule closed with ＜ 1000nM Xie From Chang Number With people NogoA polypeptide or people NiG Knot He Knot,The polynucleotides of Knitting Code Ci Class Knot conjunction molecule； Including the polynucleotides Biao Da Load Body； The polynucleotides Biao Da Xi System of molecule is closed including energy Enough Chan Sheng Knot； The host Fine born of the same parents of Righteousness Biao Da Xi System Fen From are Dinged including such as Shang； Ci Class Knot closes purposes of the molecule as Drug object,Special Do is the purposes controlled in Treatment in periphery (PNS) and/or middle Pivot (CNS) mind The system System disease； Object is closed including the Suo Shu Knot Drug Wu Group for closing molecule； With the method for controlling the periphery Treatment (PNS) and/or middle Pivot (CNS) mind The Xi System disease.本發明提供了能夠以＜1000nM的解離常數與人NogoA多肽或人NiG結合的結合分子，編碼此類結合分子的多核苷酸；包括所述多核苷酸的表達載體；包括能夠産生結合分子的多核苷酸的表達系統；包括如上定義的表達系統的分離的宿主細胞；此類結合分子作爲藥物的用途，特別是在外周(PNS)和/或中樞(CNS)神經系統疾病治療中的用途；包括所述結合分子的藥物組合物；和治療外周(PNS)和/或中樞(CNS)神經系統疾病的方法。
