The subject invention provides therapeutic compositions for use in the treatment of porcine epidemic diarrhea, comprising administering to the subject a composition comprising one or more free amino acids selected from lysine, glycine, threonine, valine, tyrosine, aspartic acid, isoleucine, tryptophan, asparagine, and serine; and optionally, therapeutically acceptable carriers, electrolytes, vitamins, buffering agents, and flavoring agents.