CHARMAN ROBERT,RIDER LONN,HONG QI,KYLE DONALD,KUPPER ROBERT
申请号：
IN4795/DELNP/2006
公开号：
IN259043B
申请日:
2006.08.22
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
A process for preparing an oxycodone hydrochloride composition having less than 25 ppm 14-hydroxycodeinone, which process comprises the steps of firstly providing an oxycodone base composition, said oxycodone base composition comprising an amount of 8a,14-dihydroxy-7,8-dihydrocodeinone, secondly reacting said oxycodone base composition with an acid under conditions suitable to convert the oxycodone base composition to an oxycodone hydrochloride composition and to promote an acid catalyzed dehydration of 8a,14-dihydroxy-7,8-dihydrocodeinone to 14-hydroxycodeinone and finally reducing an amount of 14-hydroxycodeinone in the oxycodone hydrochloride composition formed in the second step to produce an oxycodone hydrochloride composition having less than 25 ppm 14-hydroxycodeinone.
