Cerebral catheter devices and methods for use are provided. The catheter devices provided may include an anti-thrombotic agent coating on an exterior surface. The catheter devices may include unique tip configurations to allow improved fluid delivery capabilities. Further, the catheter devices may also or alternatively include one or more sensor devices in communication with a controller that allow automatically adjusting a delivery of a therapeutic fluid, for example a vasodilator, in response to a condition sensed by the catheter devices, such as increased pressure. Moreover, the catheter devices may also be used in conjunction with blood flow transducers to detect and timely prevent and treat vasospasms or other conditions. Methods for preventing and treating vasospasm, neoplasm, or other pathological conditions while prolonged using the catheter devices are also provided.
