A cryogenic biopsy device is configured to provide tissue samples that are partially frozen and partially non-frozen. This enables histopathology analysis of the intact non-frozen part of the tissue sample and assessment of the in-vivo biomolecular state of the tissue that is stabilized and maintained in the frozen part of the sample. The device of the present invention may be used in rigid instruments and in flexible devices, such as endoscopes, for example, and may be suitable for single use or multiple use.
