Provided herein is apolypeptide or formulation comprising a polypeptide for use in the treatment of a disease characterized by endothelial dysfunction, wherein the polypeptide or a fragment thereof comprising an amino acid comprising an amino acid sequence having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO: 1, 2, 3, or 4. Also provided are methods and uses relating to the same.
